8/11/2023 0 Comments Hypocretin deficiency treatmentNever disregard the medical advice of your physician or health professional, or delay in seeking such advice, because of something you read on this Site. We disclaim all responsibility for the professional qualifications and licensing of, and services provided by, any physician or other health providers posting on or otherwise referred to on this Site and/or any Third Party Site. MedHelp is not a medical or healthcare provider and your use of this Site does not create a doctor / patient relationship. It is not intended to be and should not be interpreted as medical advice or a diagnosis of any health or fitness problem, condition or disease or a recommendation for a specific test, doctor, care provider, procedure, treatment plan, product, or course of action. The Content on this Site is presented in a summary fashion, and is intended to be used for educational and entertainment purposes only. To stop doing thyroid function tests in these cases would result in considerable savings nationally in the cost of reagents in laboratories using commercial kits." These measurements are therefore of little, if any, value in monitoring patients receiving thyroxine replacement. Measurements of serum concentrations of total thyroxine, analogue free thyroxine, total triiodothyronine, analogue free triiodothyronine, and thyroid stimulating hormone, made with a sensitive immunoradiometric assay, did not, except in patients with gross abnormalities, distinguish euthyroid patients from those who were receiving inadequate or excessive replacement. In this link, it states the following: "To establish their role in monitoring patients receiving thyroxine replacement biochemical tests of thyroid function were performed in 148 hypothyroid patients studied prospectively. For your doctor, this is a good link about the lack of utility of thyroid tests, especially TSH, after thyroid meds are started. Many hypo patients do not get enough thyroid medication to raise their Free T3 and Free T4 levels enough to relieve hypo symptoms until the TSH is suppressed below its reference range. After taking thyroid meds, TSH is almost useless to monitor thyroid status. Unfortunately many doctors don't acknowledge that TSH is affected by so many variables that it is totally inadequate as the sole diagnostic for thyroid issues, even before starting on thyroid meds. (0.46, range: 0.4-4.0) When there is also a defect of either the pituitary or hypothalamus that causes a reduction of TSH secretion, isn't the best method of treatment for hypothyroidism through monitoring and elevating FT4 into the upper half of the reference range? Would it be safe to say that the TSH test would not be a reliable indicator of my thyroid state in this instance? Would this be considered both central hypothyroidism and Hashi's? Despite having obvious clinical symptoms of hyopthyroidism and a low range of FT4, the endocrinologists I have been seeing are refusing to increase my thyroid medication because my TSH is in the low end of the reference range. Interestingly, I also have Hashimoto's thyroiditis which has brought about a hypothyroid state. (journal of clinical endocrinology and metabolism). The hormones that are reduced are: LH, ACTH and TSH. Namely, it reduces several pituitary hormones by 50% or greater due to a defect in the hypothalamus where the hypocretin neuropeptide is produced. So, I have recently found out that my hypocretin deficiency (which is the cause of mynarcolepsy with severe cataplexy) also plays a critical role in the neuroendocring system.
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